Amy Schumer Reveals Her 30 Lbs Weight Loss Came at a Cost – Pics

The comedian and actress recently opened up about her 30-pound weight loss, sharing personal details about the struggles she faced along the way.

The comedian and actress, 43, discussed her experience with weight loss medications and their effects on her health during an appearance on "The Howard Stern Sirius XM Show" on January 29. While her transformation wasn't dramatic, Schumer admitted that the process wasn't easy, revealing how one popular drug left her feeling sick and drained.

Schumer shared with Stern that she had tried the medication Ozempic nearly three years ago. While some people succeeded with it, she explained that the experience was grueling for her.

"I have this gene, GDF15, which makes you extremely prone to nausea, which is why I was so sick during my pregnancy," the comedian explained. "So I tried Ozempic almost three years ago, and I was like a veteran. I was vomiting, and then you have no energy."

Furthermore, despite losing weight quickly, she said the toll it took on her body wasn't worth it. "I looked great, but I couldn't lift my head off the pillow," the actress admitted.

Over the years, Schumer's weight has fluctuated, but the most notable changes came after she became a mother. Before that, such as at the December 2013 premiere of "Anchorman 2: The Legend Continues," she appeared healthy and of average size.

Fast-forward to January 2019, she was seen attending the "Colin Quinn: Red State Blue State" opening night while heavily pregnant, glowing in maternity clothes.

Two months later, in March 2019, she appeared on "Late Night with Seth Meyers" joyfully showing off her baby bump. The actress welcomed her son, Gene, on May 5, 2019, and shared the joyful news in a now-deleted Instagram post.

In May 2019, just weeks after giving birth, Schumer was photographed with her husband, Chris Fischer, and their newborn son taking a walk in a New York City park. At the time, her body reflected the natural postpartum changes many women experience.

A few years later, at the 94th Academy Awards in March 2022, she arrived at the Dolby Theatre in Hollywood, looking confident in an elegant gown, though still visibly heavier than her pre-pregnancy self.

Her weight loss afterward was not a drastic change but a shift toward a healthier version of herself. Furthermore, the actress seems to have maintained what she lost while taking Ozempic.

On January 28, 2025, Schumer appeared on "The Tonight Show Starring Jimmy Fallon," looking radiant in a chic outfit highlighting her toned figure.

A few days later, on January 30, 2025, she participated in SiriusXM's Town Hall with Netflix's "Kinda Pregnant" cast in New York City. She appeared confident and at ease.

Schumer's openness about her struggles with the popular medication resonated with many fans, who shared their own experiences online. Some related to the difficulties, with one commenting, "It made me really super sick as well."

Others were more supportive, praising her figure. "You stopped Ozempic? I couldn't tell, you look great!" another fan wrote. Meanwhile, some netizens shared different perspectives, with one stating, "It worked great for me! I lost 85 lbs. three years ago from it and had zero side effects [sic]."